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• アンチセンスRNAとトキシン-アンチトキシン系を用いたファージセラピーの基盤技術開発
• アンチセンスRNAを用いた食品および病原性微生物における遺伝子発現制御法の開発
• トキシン-アンチトキシン系の生理機能解析およびトキシン-アンチトキシン系を活用した新規抗菌法の開発
• 次世代シーケンシング解析による食品および病原性微生物の小分子RNAの探索と機能解析
• がん診断用血清小分子RNAマーカーの探索
• マイクロRNA前駆体中に生じるRNA編集部位の探索と機能解析
• マウス精子における小分子RNAの探索と機能解析

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• 小分子機能性RNAなどに関する論文

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小分子機能性RNAなどに関する論文

Asterisk (*) shows a corresponding author and underline shows a first or joint first author.

1. Sato M., Suzuki T., Kawano M., Tamura M. Circulating osteocyte-derived exosomes contain miRNAs which are enriched in exosomes from MLO-Y4 cells. Biomedical Reports. 2017;6:223-231.

2. Tamura M, Kawano M, Sato M, Nashimoto M. Involvement of an intracellular vesicular transport process in naked-sgRNA-mediated TRUE gene silencing. Mol. Med. Rep. 2015;12(4):6365-6369.

3. Ninomiya S, Kawano M, Abe T, Ishikawa T, Takahashi M, Tamura M, Takahashi Y, Nashimoto M. Potential small guide RNAs for tRNase ZL from human plasma, peripheral blood mononuclear cells, and cultured cell lines. PLoS One. 2015;10(3):e0118631.

4. Takahashi M, Elbarbary RA, Watanabe N, Goto A, Kamiya D, Watabe Y, Uchiyama T, Narita M, Takahashi M, Ishihara N, Miyazawa T, Yoshida T, Kawano M, Tamura M, Nashimoto M: Screening of a heptamer-type sgRNA library for potential therapeutic agents against hematological malignancies. Leukemia Research. 2014;38(7):808-815.

5. Kawaji H, Lizio M, Itoh M, Kanamori-Katayama M, Kaiho A, Nishiyori-Sueki H, Shin JW, Kojima-Ishiyama M, Kawano M, Murata M, Ninomiya-Fukuda N, Ishikawa-Kato S, Nagao-Sato S, Noma S, Hayashizaki Y, Forrest AR, Carninci P; FANTOM Consortium. Comparison of CAGE and RNA-seq transcriptome profiling using clonally amplified and single-molecule next-generation sequencing. Genome Res. 2014;24(4):708-17.

6. Kouno T, de Hoon MJ, Mar JC, Tomaru Y, Kawano M, Carninci P, Suzuki H, Hayashizaki Y, Shin JW. Temporal dynamics and transcriptional control using single-cell gene expression analysis. Genome Biology. 2013;14 (10): R118.

7. Kawano M*. Divergently overlapping cis-encoded antisense RNA regulating toxin-antitoxin systems from E. coli: hok/sok, ldr/rdl, symE/symR. RNA Biol. 2012;9(12):1520-7.

8. Kawano M*, Kawaji H, Grandjean V, Kiani J, Rassoulzadegan M. Novel Small noncoding RNAs in Mouse Spermatozoa, Zygotes and Early Embryos. PLoS One. 2012;7(9):e44542.

9. Ando Y, Burroughs A, Kawano M, de Hoon MJ, Hayashizaki Y. Targeted Methods to Improve Small RNA Profiles Generated by Deep Sequencing. Regulatory RNAs: Basics and Applications. 2012;253-72.

10. Burroughs AM, Kawano M*, Ando Y, Daub CO, Hayashizaki Y. pre-miRNA profiles obtained through application of locked nucleic acids and deep sequencing reveals complex 5'/3' arm variation including concomitant cleavage and polyuridylation patterns. Nucleic Acids Res. 2012;40(4):1424-37.

11. Shinohara Y, Yahagi K, Kawano M, Nishiyori H, Kawazu C, Suzuki N, Manabe R, Hirase H. miRNA profiling of bilateral rat hippocampal CA3 by deep sequencing. Biochem Biophys Res Commun. 2011;409(2):293-8.

12. Kawano M*, Kawazu C, Lizio M, Kawaji H, Carninci P, Suzuki H, Hayashizaki Y. Efficient small RNA library preparation protocol. Biotechniques Protocol Guide. 2011;4-6.

13. Kawano M*, Kawazu C, Lizio M, Kawaji H, Carninci P, Suzuki H, Hayashizaki Y. Reduction of non-insert sequence reads by dimer eliminator LNA oligonucleotide for small RNA deep sequencing. Biotechniques. 2010;49(4):751-5.

14. de Hoon MJ, Taft RJ, Hashimoto T, Kanamori-Katayama M, Kawaji H, Kawano M, Kishima M, Lassmann T, Faulkner GJ, Mattick JS, Daub CO, Carninci P, Kawai J, Suzuki H, Hayashizaki Y. Cross-mapping and the identification of editing sites in mature microRNAs in high-throughput sequencing libraries. Genome Res. 2010;20(2):257-64.

15. Fozo EM, Kawano M, Fontaine F, Kaya Y, Mendieta KS, Jones KL, Ocampo A, Rudd KE, Storz G. Repression of small toxic protein synthesis by the Sib and OhsC small RNAs. Mol Microbiol. 2008;70(5):1076-93.

16. Kawano M, Aravind L, Storz G. An antisense RNA controls synthesis of an SOS-induced toxin evolved from an antitoxin. Mol Microbiol. 2007;64(3):738-54.

17. Kanie S, Horibata K, Kawano M, Isogawa A, Sakai A, Matsuo N, Nakanishi M, Hasegawa K, Yoshiyama K, Maki H. Roles of RecA protein in spontaneous mutagenesis in Escherichia coli. Genes Genet Syst. 2007;82(2):99-108.

18. Kawano M, Storz G, Rao BS, Rosner JL, Martin RG. Detection of low-level promoter activity within open reading frame sequences of Escherichia coli. Nucleic Acids Res. 2005;33(19):6268-76.

19. Kawano M, Reynolds AA, Miranda-Rios J, Storz G. Detection of 5'- and 3'-UTR-derived small RNAs and cis-encoded antisense RNAs in Escherichia coli. Nucleic Acids Res. 2005;33(3):1040-50.

20. Kawano M, Oshima T, Kasai H, Mori H. Molecular characterization of long direct repeat (LDR) sequences expressing a stable mRNA encoding for a 35-amino-acid cell-killing peptide and a cis-encoded small antisense RNA in Escherichia coli. Mol Microbiol. 2002;45(2):333-49.

21. Kawano M, Kanaya S, Oshima T, Masuda Y, Ara T, Mori H. Distribution of repetitive sequences on the leading and lagging strands of the Escherichia coli genome: comparative study of Long Direct Repeat (LDR) sequences. DNA Res. 2002;9(1):1-10.